主要招生专业： 遗传学 生物化学与分子生物学 学科教育（生物学） 主要研究方向： 人类遗传学 医学遗传学 营养基因组学 近三年代表论文、著作和奖励： *：通讯作者 1. Xihan Guo, Henning Hintzsche, Weijiang Xu, Juan Ni, Jinglun Xue, Xu Wang*. Interplay of cGAS with micronuclei: Regulation and diseases. Mutation Research-Reviews in Mutation Research 2022,790,108440 2. Xihan Guo, Chunlei Wang, Weimeng Tian, Xueqin Dai, Juan Ni, Xiayu Wu and Xu Wang. Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation Mutagenesis, 2021, 36, 95–107 3. Lin Lu, Hongbo Zhao, Jianjun Liu, Yuwen Zhang, and Xu Wang*. miRNA-mRNA Regulatory Network Reveals miRNAs in HCT116 in Response to Folic Acid Deficiency via Regulating Vital Genes of Endoplasmic Reticulum Stress Pathway. BioMed Research International 2021, https://doi.org/ 10.1155/2021/6650181 4. Xihan Guo，Xueqin Dai，Xue Wu，Neng Cao, Xu Wang*. Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes. Int. J. Cancer. 2021, 48:812–824. 5. Xialian Hu , Xihan Guo , Juan Ni, Han Wang, Neng Cao, Ziqing Liang, Xu Wang *, High homocysteine promotes telomere dysfunction and chromosomal instability in human neuroblastoma SH-SYSY cells. Mutat Res Gen Tox En. 2020,854-855. 6. Xihan Guo, Xueqin Dai, Tao Zhou, Han Wang, Juan Ni, Jinglun Xue, Xu Wang*. Mosaic loss of human Y chromosome: what, how and why. Human Genetics. 2020,139:421–446. 7. Han Wang, Juan Ni, Xihan Guo, Tao Zhou, Xiaoling Ma, Jinglun Xue, Xu Wang*. Shelterin differentially respond to oxidative stress induced by TiO2-NPs and regulate telomere length in human hepatocytes and hepatocarcinoma cells in vitro. BBRC, 2018,503:697-702 8. Juan Ni, Xihan Guo, Han Wang, Tao Zhou and Xu Wang. Differences in the Effects of EGCG on Chromosomal Stability and Cell Growth between Normal and Colon Cancer Cells，Molecules, 2018, 23, (4): 788. 9. Juan Ni; YaoXian Liu; Tao Zhou; XiaYu Wu; Xu Wang*. Single Nucleotide Polymorphisms in Key One-Carbon Metabolism Genes and Their Association with Blood Folate and Homocysteine Levels in a Chinese Population in Yunnan. Genet Test Mol Biomarkers, 2018, 22(3):193-198. 10. Xihan Guo, Juan Ni, Xueqin Dai, Tao Zhou, Guofang Yang, Jinglun Xue, Xu Wang*. Biphasic regulation of spindle assembly checkpoint by low and high concentrations of resveratrol leads to the opposite effect on chromosomal instability. Mutat Res Gen Tox En , 2018, 825:19-30. 11. Xihan Guo, Han Wang, Juan Ni, Ziqing Liang, Xiayu Wu, Jinglun Xue and Xu Wang*. Geraniin selectively promotes cytostasis and apoptosis in human colorectal cancer cells by inducing catastrophic chromosomal instability. Mutagenesis, 2018, 33: 271-281. 12. Xihan Guo, Juan Ni, Ziqing Liang, Jinglun Xue, Michael Fenech*, Xu Wang* The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem. Mutation Research-Reviews in Mutation Research, 2019,779 :1-35. 13. 李剑飞，郭锡汉，薛京伦，汪旭*. 叶酸对阿尔茨海默病的影响及其机制研究进展 癌变.畸变.突变. 2021,33: 317-320 14. 王晗，倪娟，周滔，杨国防，汪旭*. 纳米颗粒诱导肝脏毒性的研究进展.癌变.畸变.突变, 2018, 30(4):315-317. 15. 胡夏练，郭锡汉，马晓玲，汪旭*. 同型半胱氨酸增加阿尔兹海默症患病风险相关机制的研究进展. 癌变.畸变.突变, 2018,30(5):403-406. 16. 王晗，倪娟，薛京伦，汪旭*. 端粒蛋白复合物shelterin 的结构及功能研究进展. 癌变.畸变.突变, 2019, 31 (3):253-255 17. 曹宇，倪娟，曹能，杨国防，薛京伦，汪旭*. Gadd45蛋白家族在肿瘤发生发展中的作用. 肿瘤防治研究, 2019,46(3):271-274 18. 薛京伦，潘雨堃，陈金中，汪旭 主编《医学分子遗传学》（第五版），科学出版社，2018. 19. 汪旭，倪娟，郭锡汉，王晗，周滔，一碳代谢关键组分及几种植物营养素对人类基因组稳定性的影响与机制研究 2021年云南省自然科学二等奖 (2021NA002-R-001) 近三年主持的国家级或百万以上其他项目： 1. 国家自然科学基金. MicroRNA应答一碳单位代谢主要组分缺乏并调控错配修复通路核心基因表达的机制研究 2016,01-2019,12 2. 国家自然科学基金. miRNAs应答同型半胱氨酸代谢变化对人神经细胞Aβ/tau生成与加工路径核心基因表达调控的机制研究 2019,01-2022,12 3. 基因组损伤诊断/矫正数据库建设与干预产品研发, 与华夏基因健康管理集团合作,140万，2015,10-2021,10 近三年主持的省级以上教学质量工程项目： 生物科学-国家级特色专业 分子生物学-国家级双语示范课程 分子生物学 省级一流课程（2019，2020） 近三年主讲课程（研究生，本科）： 博士生课程：表观遗传学 硕士生课程：遗传毒理学，医学分子遗传学 本科生课程：分子生物学，医学分子遗传学，生命科学进展 |
