学历及研究简历:（从本科起正序） 2005年9月- 2009年7月 中国农业大学 生物学院 学士 2009年7月- 2014年4月 新加坡南洋理工大学 生物学院 博士
代表论文和著作： 1.Enheng Zhu, Xia Xiang, Sidi Wan, Huabiao Miao, Nanyu Han*, Zunxi Huang*, Discovery of the key mutation site influencing the thermostability of Thermomyces lanuginosus lipase by Rosetta design programs. International Journal of Molecular Sciences (2022) 23: 8963. 2.Nanyu Han#, Minyuan Tang#, Sidi Wan, Zhanbao Jiang, Yong Yue, Xiangui Zhao, Jinrun Yang, Zunxi Huang*, Surface charge engineering of Thermomyces lanuginosus lipase improves enzymatic activity and biodiesel synthesis. Biotechnology Letters (2021) 43: 1403-1411. 3.Huabiao Miao, Yu Ma, Yuanyuan Zhe, Xianghua Tang, Qian Wu, Zunxi Huang*, Nanyu Han*, Improving the thermostability of a fungal GH11 xylanase via fusion of a submodule (C2) from hyperthermophilic CBM9_1-2. International Journal of Molecular Sciences (2021) 23:463. 4.Nanyu Han, Justin Tze Yang Ng, Yanpeng Li, Yuguang Mu*, Zunxi Huang*, Plasticity of the 340-Loop in influenza neuraminidase offers new insight for antiviral drug development. International Journal of Molecular Sciences (2020) 21:5655. 5.Zhanbao Jiang, Chengbo Zhang, Minyuan Tang, Bo Xu, Lili Wang, Wen Qian, Jiandong He, Zhihong Zhao, Qian Wu, Yuelin Mu, Junmei Ding, Rui Zhang, Zunxi Huang*, Nanyu Han*, Improving the thermostability of Rhizopus Chinensis lipase through site-directed mutagenesis based on B-factor analysis. Frontiers in Microbiology (2020) 11:346. 6.Nanyu Han#, Yu Ma#, Yuelin Mu, Xianghua Tang, Junjun Li, Zunxi Huang*, Enhancing thermal tolerance of a fungal GH11 xylanase guided by B-factor analysis and multiple sequence alignment. Enzyme and Microbial Technology (2019) 131:109422. 7.Nanyu Han#, Huabiao Miao#, Tingting Yu, Bo Xu, Yunjuan Yang, Qian Wu, Rui Zhang, Zunxi Huang*, Enhancing thermal tolerance of Aspergillus niger PhyA phytase directed by structural comparison and computational simulation. BMC Biotechnology (2018) 18:36. 8.Nanyu Han#, Huabiao Miao#, Junmei Ding, Junjun Li, Yuelin Mu, Junpei Zhou, Zunxi Huang*, Improving the thermostability of a fungal GH11 xylanase via site-directed mutagenesis guided by sequence and structural analysis. Biotechnology for Biofuels (2017) 10:133. 9.Nanyu Han, Yuguang Mu, Huabiao Miao, Yunjuan Yang, Qian Wu, Junjun Li, Junmei Ding, Bo Xu, Zunxi Huang*, The 340-cavity in neuraminidase provides new opportunities for influenza drug development: A molecular dynamics simulation study. Biochemical and Biophysical Research Communications (2016), 470(1):130-136. 10.Nanyu Han, Yuguang Mu*, Locking the 150-cavity open: In silico design and verification of influenza neuraminidase inhibitors. PLoS ONE (2013) 8:8. 11.Nanyu Han, Yuguang Mu*, Plasticity of 150-Loop in influenza neuraminidase explored by Hamiltonian replica exchange molecular dynamics simulations. PLoS ONE (2013) 8:4. 12.Nanyu Han, Xuewei Liu, Yuguang Mu*, Exploring the mechanism of Zanamivir resistance in a neuraminidase mutant: A molecular dynamics study. PLoS ONE (2012) 7:9. 13.Jiahai Shi#, Nanyu Han#, Liangzhong Lim, Shixiong Lua, J. Sivaraman, Lushan Wang, Yuguang Mu*, Jianxing Song*, Dynamically-driven inactivation of the catalytic machinery of the SARS 3C-Like protease by the N214A mutation on the extra domain. PLoS Computational Biology (2011) 7:2.
获奖成果： 1.指导曹艳、李志怡、崔克玲、滕雨荷同学获得第四届全国大学生生命科学竞赛（2020年）全国一等奖 2.指导顾明霞同学获得2022届云南师范大学本科生优秀毕业论文
主持的国家级或其他项目： 1.国家自然科学基金（32160217）：基于Ser/Thr替换的木聚糖酶XynCDBFV耐热机制及优化策略研究，经费：34万，2022.01-2025.12（主持） 2.国家自然科学基金（31660240）：流感病毒神经氨酸酶NA与Ca2+的互作机制及药物靶点研究，经费：38万，2017.01-2020.12.（主持） 3.云南省自然科学面上项目（202201AT070033）：计算机辅助设计提高脂肪酶TLL耐热性及耐热机制研究，10万，2022.06-2025.05（主持） 4.云南省自然科学青年项目（2016FD018）：高通量筛选抗流感病毒中药组分及作用机制研究，6万，2016.10-2019.09（主持） 5.云南师范大学优秀青年学者项目，第五批，2021.01-2023.12（主持）
近三年主讲课程： 1.《现代微生物学及研究方法》 2.《微生物学实验》 3.《解密传染病》 |
